All products are for laboratory research use only. Not for human consumption.
Growth Hormone
The Dual Secretagogue
RM 450
Awaken timeless vitality. This 10mg master blend unites sustained signaling with gentle release, optimizing your body’s natural growth hormone rhythms.
For research use only. Not for human or veterinary consumption. This product is not a medicine and is not intended to diagnose, treat, cure or prevent any disease.
Overview
Two distinct GH receptor pathways activated simultaneously: CJC-1295 (DAC) binds the GHRH receptor with a 6-8 day half-life for sustained baseline elevation, while Ipamorelin selectively activates GHSR-1a with zero cortisol, prolactin, or ACTH elevation. Together they produce a GH pulse 3-10x larger than either alone — with fully intact pituitary feedback.
Mechanism of action
6-8 day half-life via Drug Affinity Complex albumin binding
The cleanest GH secretagogue — zero cortisol at any dose
Maximum physiological GH pulse with preserved pituitary feedback
Key finding Simultaneous GHRH receptor (CJC-1295 DAC) and ghrelin receptor (Ipamorelin) activation produces a GH pulse 3-10x above physiological baseline with zero cortisol elevation — impossible to achieve with either compound alone.
Key research findings
CJC-1295 (DAC) half-life in human pharmacokinetic study — 15-30x longer than unmodified GHRH
Teichman SL et al. J Clin Endocrinol Metab, 2006Cortisol or prolactin elevation at any Ipamorelin dose studied in human subjects
Raun K et al. Eur J Endocrinol, 1998GH pulse amplification above baseline with combined CJC-1295 + Ipamorelin administration
Combined secretagogue pharmacology dataPituitary suppression or axis downregulation — unlike exogenous synthetic HGH
Multiple GH secretagogue studiesResearch areas
The most physiologically complete GH stimulation available — both GHRH and ghrelin receptor activation simultaneously.
Sustained GH elevation from CJC-1295 DAC combined with Ipamorelin pulses drives anabolic body composition changes.
GH axis decline is a primary marker of aging. This combination represents the most validated GH restoration approach.
GH is the primary recovery and repair hormone. Maximizing clean GH pulses has broad tissue repair implications.
Safety profile
GH elevation increases IGF-1, which has downstream anabolic and proliferative effects. Research protocols should account for this in sensitive model systems.
GH stimulation elevates IGF-1 — theoretical proliferative concern in oncology models
GH-mediated water retention possible at higher research doses
GH can reduce insulin sensitivity — monitor in diabetic research models
Both compounds rely on intact pituitary function — verify in research subjects
Molecular profile
Frequently asked questions
DAC (Drug Affinity Complex) is a chemical modification that allows CJC-1295 to bind albumin — the most abundant protein in blood. This extends half-life from approximately 30 minutes (unmodified GHRH) to 6-8 days. The result is sustained GHRH receptor stimulation between research administrations without continuous dosing.
GHRP-2 raises cortisol by ~40% and prolactin by ~25%. GHRP-6 raises cortisol by ~60%. Ipamorelin raises neither cortisol nor prolactin at any studied dose — it is the only GHSR-1a agonist with this clean profile. For research where cortisol confounding must be eliminated, Ipamorelin is the only viable choice.
No. Both compounds stimulate the pituitary gland to produce its own GH. Natural negative feedback mechanisms remain intact — when GH rises, the pituitary self-regulates. This is the fundamental difference from exogenous HGH, which suppresses pituitary function.
The GHRH receptor (CJC-1295) and the ghrelin receptor (GHSR-1a) activate GH secretion through independent intracellular signaling cascades. When both are activated simultaneously, the GH response is 3-10x larger than activating either one alone — true synergy, not simple addition.
CJC-1295 (DAC): 6-8 days half-life provides sustained baseline GH elevation. Ipamorelin: ~2 hour half-life produces a GH pulse within 30-60 minutes of administration. Together they provide both sustained baseline elevation and pulsatile GH amplification.
Secretagogues stimulate the pituitary to produce endogenous GH — the resulting GH is your own, pulsatile, and regulated by natural feedback. Exogenous HGH bypasses the pituitary entirely and suppresses its function over time. Secretagogues maintain a physiological pattern; HGH does not.
References
