All products are for laboratory research use only. Not for human consumption.
Longevity · Restores Immune Function
The Cellular Preserver
RM 450
Defy time at the source. Epithalon 50 mg activates deep longevity pathways, protecting your cellular blueprint for true, ageless vitality.
For research use only. Not for human or veterinary consumption. This product is not a medicine and is not intended to diagnose, treat, cure or prevent any disease.
Overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide derived from Epithalamin — a natural pineal gland extract. Developed and studied for over 40 years at the St. Petersburg Institute of Bioregulation and Gerontology by Professor Vladimir Khavinson, it is the most studied telomere-activating compound known. Primary mechanism: direct stimulation of telomerase (TERT), the enzyme responsible for maintaining chromosome ends.
Mechanism of action
Directly stimulates TERT — the catalytic subunit of telomerase
Restores pineal gland function that declines with age
Reduces oxidative stress and demonstrates oncostatic properties
Key finding Epithalon is the only compound demonstrated to elongate telomeres in human somatic cells in a controlled study — directly stimulating telomerase TERT activity. Combined with 24% lifespan extension in animal models, it represents the most validated telomere-targeting intervention known.
Key research findings
Mean lifespan extension in Drosophila melanogaster (fruit fly) model with Epithalon treatment
Khavinson VK et al. Mech Ageing Dev, 2000Telomere elongation and telomerase TERT activation demonstrated in human somatic cell cultures
Khavinson VK et al. Bull Exp Biol Med, 2003Restoration of age-reduced melatonin secretion and normalization of circadian melatonin rhythm
Anisimov VN et al. Oncol Rep, 2006Inhibition of tumor development and extension of cancer-free lifespan in mammary tumor mouse models
Anisimov VN et al. Int J Cancer, 2002Research areas
The only compound with published evidence of telomere elongation in human somatic cells — the most direct cellular aging intervention known.
Pineal gland restoration and melatonin normalization — critical for circadian rhythm and sleep quality research.
T-cell and NK cell enhancement in elderly subjects — immune longevity research.
Oncostatic properties — inhibits tumor growth in animal models — relevant to cancer prevention research.
Safety profile
40+ years of research and clinical application in Russia with a favorable safety profile. Primary consideration is theoretical telomerase-related risk in oncology contexts.
Theoretical: telomerase reactivation is a feature of cancer cells — note in oncology models
Epithalon shows oncostatic activity in animal models, but telomerase concern warrants caution
T-cell and NK cell enhancement — note in autoimmune research contexts
Melatonin normalization may interact with melatonin-sensitive research models
Molecular profile
Frequently asked questions
Epithalon stimulates the expression and activity of TERT — the catalytic subunit of telomerase. TERT is the enzyme that adds repetitive TTAGGG sequences to the ends of chromosomes, counteracting the progressive shortening that occurs with each cell division. Khavinson demonstrated that Epithalon can elongate telomeres in human somatic cell cultures — an effect that had been considered achievable only in germ cells and stem cells.
Epithalon is a synthetic version of Epithalamin — a polypeptide extract from the pineal gland studied by Professor Khavinson since the 1970s. The pineal gland is the primary source of melatonin and is considered a key regulator of aging. The gland progressively calcifies and reduces melatonin output with age. Epithalon mimics and restores the active components of pineal signaling.
In Drosophila melanogaster (fruit fly) experiments, Epithalon extended mean lifespan by approximately 24%. Fruit flies are a standard model organism for longevity research because of their short lifespan (~60-80 days) and well-characterized genetics. While translation to humans requires significant qualification, a 24% lifespan extension in any model organism with a single compound is an extraordinary finding.
They are related but distinct. Epithalamin is a natural polypeptide extract from bovine pineal glands — containing multiple peptide fractions. Epithalon (AEDG) is the synthetic tetrapeptide identified by Professor Khavinson as the primary active component of Epithalamin, with more consistent composition and purity than the natural extract.
Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology has published over 700 research papers and holds numerous patents. His work on Epithalon spans 40+ years and includes: lifespan studies in fruit flies, rodents, and monkeys; telomere elongation in human cells; oncostatic activity in cancer models; melatonin normalization; and immune function improvement in elderly subjects.
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