All products are for laboratory research use only. Not for human consumption.
Skin & Aesthetics · Regenerative - Anti-Aging
The Skin & Tissue Remodeler
RM 360
Unlock your sovereign radiance. GHK-Cu 50 mg is the ultimate beauty peptide, resetting your skin’s architecture from the cell up.
For research use only. Not for human or veterinary consumption. This product is not a medicine and is not intended to diagnose, treat, cure or prevent any disease.
Overview
GHK-Cu modulates the expression of more than 4,000 human genes — approximately 31% of the entire human genome. This extraordinary breadth means a single tripeptide simultaneously upregulates collagen synthesis, DNA repair, antioxidant defense, and anti-inflammatory signaling while downregulating cancer-promoting and inflammatory genes.
Mechanism of action
4,000+ genes — the broadest genomic reach of any known peptide
Delivers bioavailable copper to critical enzymes requiring it as cofactor
Activates DNA repair pathways and protects nuclear integrity
Key finding GHK-Cu modulates 31% of the human genome through two transcription factors (SP1 and NF-kB), simultaneously upregulating 2,802 genes and downregulating 1,309 genes — the broadest genomic regulatory reach of any known peptide compound.
Key research findings
Wrinkle depth reduction versus control in double-blind clinical split-face study at 8 weeks
Pickart L, Margolina A. Cosmetics, 2019Photodamage reduction versus control in double-blind clinical study using GHK-Cu formulation
Pickart L et al. Cosmetics, 2015Human genes modulated by GHK-Cu in microarray analysis — 2,802 upregulated, 1,309 downregulated
Pickart L, Margolina A. Cosmetics, 2019Significant increase in collagen synthesis in fibroblast cell culture studies at nanomolar concentrations
Maquart FX et al. FEBS Lett, 1988Research areas
The most genomically validated aesthetic peptide — clinical evidence for wrinkle reduction, photodamage repair, and collagen synthesis.
Modulates 31% of the human genome — research implications across oncology, inflammation, aging, and regenerative medicine.
Accelerates wound repair through simultaneous collagen upregulation, angiogenesis support, and anti-inflammatory gene activation.
Copper delivery to SOD plus DNA repair pathway activation provides comprehensive oxidative stress protection.
Safety profile
GHK-Cu has an exceptional safety profile established over 50+ years of research. The primary consideration is copper homeostasis at very high doses, which is not relevant at standard research concentrations.
At very high non-physiological doses, copper accumulation is theoretical — not relevant at standard research concentrations
Promotes cell proliferation and migration — note in oncology research contexts
Modulation of 4,000+ genes means off-target effects are theoretically possible — well-characterized in literature
May interact with other metal-chelating compounds or metal-dependent therapeutics
Molecular profile
Frequently asked questions
GHK-Cu activates two master transcription factors: SP1 and NF-kB — but in a regulatory, not inflammatory, mode. SP1 alone controls expression of hundreds of genes involved in cell growth, differentiation, and repair. NF-kB in its regulatory form drives anti-inflammatory and protective genes. Additionally, the copper component modulates hypoxia-inducible factors (HIF). The cumulative downstream reach of these cascades is 31% of the human genome.
Multiple double-blind split-face clinical studies have demonstrated measurable anti-aging effects: -31% wrinkle depth reduction and 52% photodamage reduction versus control at 8 weeks using GHK-Cu formulations. These are human clinical studies, not just cell culture or animal data.
Topical GHK-Cu is limited by skin penetration depth — effective for superficial skin layers but cannot deliver systemic concentrations. Injectable research preparations deliver GHK-Cu systemically, enabling it to reach all tissues, organs, and cells throughout the body, accessing the full 4,000+ gene modulation capability.
GHK-Cu has a large effective dose range for different research applications. The 50mg vial provides flexibility for higher-concentration protocols and extended research duration without frequent re-ordering. It also enables consistent stock for multi-experiment protocols.
Yes. GHK-Cu (Glycyl-L-histidyl-L-lysine copper complex) is naturally found in human blood plasma. Concentration is approximately 200ng/mL in young adults, declining to approximately 80ng/mL by age 60. This age-related decline correlates with many signs of skin and tissue aging, making GHK-Cu restoration research particularly relevant.
GHK-Cu specifically has been the subject of 50+ years of dedicated research by Loren Pickart and others, producing a uniquely deep literature. Other copper peptides exist but lack comparable evidence. The specific Gly-His-Lys sequence creates a copper binding geometry that activates the specific transcription factor cascades documented in peer-reviewed literature.
References
